Clinical study on Shenshuaining Granules combined with reduced glutathione in treatment of chronic renal failure during maintenance hemodialysis
Objective To investigate the clinical effect of Shenshuaining Granules combined with Reduced Glutathione for injection in treatment of chronic renal failure during maintenance hemodialysis.Methods Patients(80 cases)with chronic renal failure during maintenance hemodialysis in the Fourth People's Hospital of Lianyungang from January to October 2023 were divided into control and treatment groups according to the random number table method,with 40 cases in each group.Patients in the control group were iv administered with Reduced Glutathione for injection,1.5 g/m2 added into normal saline 100 mL,once daily.Patients in the treatment group were po administered with Shenshuanning Granules on the basis of the control group,1 bag/time,three times daily.Patients in two groups were treated for 45 d.The clinical efficacies,disease degree,renal function indexes,oxidative stress indexes,and red blood cell parameters in two groups were compared.Results The total effective rate was 92.50%in the treatment group and 75.00%in the control group,and the difference was significant between the treatment group and the control group(P＜0.05).After treatment,APACHEⅡ score of two groups was lower than that before treatment(P＜0.05),and APACHEⅡ score of the treatment group was lower than that of the control group(P＜0.05).After treatment,GFR was higher than that before treatment,but Scr,UTP,and β2-MG were lower than that before treatment(P＜0.05).GFR in the treatment group was higher than that in the control group,but Scr,UTP,and β2-MG were lower than that in the control group(P＜0.05).The serum levels of SAA,AGEs,and AOPP of two groups were lower than those before treatment(P＜0.05),and the serum levels of SAA,AGEs,and AOPP in the treatment group were lower than those in the control group(P＜0.05).After treatment,HCT and Hb in two groups were higher than before treatment(P＜0.05),and HCT and Hb in the treatment group were higer than those in the control group(P＜0.05).Conclusion Shenshuaining Granules combined with Reduced Glutathione for injection can improve the therapeutic effect of chronic renal failure during maintenance hemodialysis,further control the disease,improve renal function and red blood cell function,and reduce oxidative stress response.
Shenshuanning GranulesReduced Glutathione for injectionchronic renal failure during maintenance hemodialysisAPACHEⅡ scoreGFRβ2-MGSAAAGEsAOPPHCTHb
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