Clinical study on Fuyanxiao Capsules combined with metronidazole in treatment of bacterial vaginitis
Objective To explore the clinical efficacy of Fuyanxiao Capsules combined with Metronidazole Tablets in treatment of bacterial vaginitis.Methods Patients(120 cases)with bacterial vaginitis in the 7th People's Hospital of Zhengzhou from January 2021 to January 2023 were divided into control and treatment groups according to the envelope randomization method,and each group had 60 cases.Patients in the control group were po administered with Metronidazole Tablets,2 tablets/time,twice daily.Patients in the treatment group were po administered with Fuyanxiao Capsules on the basis of the control group,3 grains/time,three times daily.Patients in two groups were treated for 1 week.The clinical efficacies,recurrence rates,the symptom improvement time,oxidative stress indicators,and inflammatory response indicators in two groups were compared.Results After treatment,the effective rate of the treatment group(95.00%)was higher than 83.33%of the control group,and the recurrence rate(6.67%)was lower than 20.00%of the control group,with statistical significance between two groups(P＜0.05).After treatment,the improvement time of vaginal wall congestion,abnormal vaginal discharge,burning sensation after urination,lower abdominal distension,and itching at the vaginal opening in the treatment group was shorter than that in the control group(P＜0.05).After treatment,the serum levels of SOD in two groups increased but serum levels of NO,MDA,hs-CRP,IL-6,and TNF-α in two groups decreased(P＜0.05).The serum levels of SOD in the treatment group were higher than those in the control group,but serum levels of NO,MDA,hs-CRP,IL-6,and TNF-α in the treatment group were lower than those in the control group(P＜0.05).Conclusion Fuyanxiao Capsules combined with Metronidazole Tablets is effective in treatment of bacterial vaginitis,which is beneficial for shortening the time for clinical symptom improvement,improving oxidative stress response,reducing inflammatory factor indicators,and preventing disease recurrence.
Fuyanxiao CapsulesMetronidazole Tabletsbacterial vaginitisrecurrence rateimprovement time for vaginal itchingSODNOMDAhs-CRPIL-6TNF-α
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