Objective To explore the effects of Guizhi Fuling Capsules combined with doxycycline in treatment of chronic endometritis.Methods A total of 80 patients with chronic endometritis after repeated implantation failure admitted to Department of Reproductive Gynecology of Nanyang First People's Hospital from August 2021 to July 2023 were selected and divided into control group and treatment group according to different treatment plans,with 40 cases in each group.Patients in the control group were po administered with Doxycycline Hyclate Tablets,0.1 g/time,twice daily.Patients in treatment group were po administered with Guizhi Fuling Capsules on the basis of control group,1 grain/time,twice daily.Both groups were treated continuously for 14 d starting from the first day of menstruation.The clinical efficacy and symptom remission time of two groups were observed,and the changes of endometrial indexes and serum inflammatory factors before and after treatment were compared between two groups.Results After treatment,the total effective rate of the treatment group was 82.50%,which was significantly higher than that of the control group(67.50%,P＜0.05).After treatment,the relief time of lower abdominal pain,lower abdominal distension,prolonged menstrual period and heavy menstrual volume in treatment group was significantly shorter than that in control group(P＜0.05).After treatment,endometrial thickness and subendometrial blood flow index in 2 groups were significantly increased compared with before treatment(P＜0.05).After treatment,endometrial thickness and subendometrial blood flow index in treatment group were higher than those in control group(P＜0.05).After treatment,the levels of interleukin1β(IL-1β),vascular endothelial growth factor(VEGF),tumor necrosis factor-α(TNF-α)and hypoxia-inducing factor 1α(HIF-1α)in 2 groups were significantly decreased compared with those before treatment(P＜0.05).After treatment,the levels of IL-1β,VEGF,TNF-α and HIF-1α in treatment group were lower than those in control group(P＜0.05).Conclusion Guizhi Fuling Capsules combined with doxycycline has good clinical efficacy in treatment of chronic endometritis,and can effectively improve the relevant symptoms of patients and reduce the degree of endometrial inflammatory reaction,which is worthy of clinical reference and application.
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