Clinical study on amphotericin B combined with hydrogen peroxide in treatment of fungal otitis externa
Objective To explore the clinical effect of amphotericin B combined with hydrogen peroxide in treatment of fungal otitis externa.Methods Patients(82 cases)with fungal otitis externa in Qingdao Chengyang People's Hospital from September 2021 to September 2023 were randomly divided into control(41 cases)and treatment(41 cases)group.Patients in the control group were administered with Hydrogen Peroxide Solution,rinsed external ear canal with 3%solution,three times daily.Patients in the treatment group were administered with Amphotericin B for injection on the basis of the control group,25 mg added into injection water 5 mL for 10 min,three times daily.Patients in two groups were treated for 14 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,the AC and BC hearing thresholds,the levels of serum TNF-α,PCT,TGF-β1 and IL-6 in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 92.68%,which was significantly higher than that of the control group(78.05%,P＜0.05).After treatment,the time of symptom relief in the treatment group was significantly earlier than that in the control group(P＜0.05).After treatment,the AC hearing threshold and BC hearing threshold in two groups were significantly lower than those before treatment(P＜0.05),and which in the treatment group were lower than those of the control group(P＜0.05).After treatment,the levels of serum TNF-α,PCT,TGF-β1 and IL-6 in two groups were lower than those before treatment,and which in the treatment group were significantly lower than those in the control group(P＜0.05).Conclusion The synergistic treatment of hydrogen peroxide solution and amphotericin B is effective in improving the symptoms of the affected ear,can obviously alleviate the hearing ability and reduce the inflammatory reaction of the external auditory canal.
Amphotericin B for injectionHydrogen Peroxide Solutionfungal external otitisbone conduction hearing thresholdPCTTGF-β1
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