Clinical study of Compound Zhenzhu Kouchuang Granules combined with Kangfuxin Liquid in treatment of oral ulcer
Objective To investigate the clinical efficacy of Compound Zhenzhu Kouchuang Granules combined with Kangfuxin Liquid in treatment of oral ulcer.Methods A total of 96 patients with oral ulcer admitted to Anting Hospital of Jiading District in Shanghai from July 2020 to June 2023 were selected and divided into control group and treatment group according to random number table method,with 48 cases in each group.Patients in the control group were given Kangfuxin Liquid,10 mL/time with gargling for 5 min each time,three times daily.Avoid gargling,drinking and fasting within 30 min after medication.Patients in the treatment group were given Compound Zhenzhu Kouchuang Granules on the basis of the control group,1 bag/time,twice daily,dissolved in 100 mL boiling water 30 min after meal,swallowed slowly after 1—2 minutes each time,and used up within 10 min.The treatment course of both groups was 1 week.The efficacy,pain relief,and ulcer healing time were observed.The visual analogue scale(VAS)for pain,14-item Oral Health Impact Profile(OHIP-14),Symptom Checklist-90(SCL-90)scores,and serum interleukin-17(IL-17),complement C3,C4,superoxide dismutase(SOD),and transforming growth factor-beta(TGF-β)levels were compared in two groups before and after treatment.Results After treatment,the total effective rate of the treatment group was 97.92%,which was significantly higher than that of control group(83.33%)(P＜0.05).After treatment,the pain relief time and ulcer healing time in treatment group were significantly shorter than those in control group(P＜0.05).After treatment,pain VAS,OHIP-14,and SCL-90 scores were significantly decreased in both groups(P＜0.05).After treatment,VAS,OHIP-14,and SCL-90 scores in the treatment group were lower than those in control group(P＜0.05).After treatment,serum IL-17 levels were significantly decreased in both groups,but serum complement C3,C4,SOD,TGF-β levels were significantly increased(P＜0.05).After treatment,the levels of IL-17,complement C3,complement C4,SOD and TGF-β in treatment group were better than those in control group(P＜0.05).Conclusion Compound Zhenzhu Kouchuang Granules combined with Kangfuxin Liquid has a good effect in treatment of oral ulcer,and can effectively promote patients'pain relief and ulcer surface healing,regulate immune disorders and inflammatory response,and improve patients'condition recovery,psychological state and life quality,which is worthy of clinical application.
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