Literature analysis of adverse reactions induced by palbociclib
Objective To investigate the occurrence pattern and clinical manifestation characteristics of adverse drug reactions caused by palbociclib,and to provide reference for its safe clinical use.Methods Case reports of adverse reactions caused by palbociclib were retrieved from CNKI,Wanfang Data,VIP,PubMed,and Web of Science literature databases from December 2023 and analyzed statistically.Results Forty literatures were included,involving 44 patients,all of whom were female and most of whom were over 60 years old.The occurrence time was from 1 d to 15 months after medication,mainly in the first 3 months(63.64%).Involving skin,respiratory system,blood system,nervous system and other body organs/systems.33 patients improved after drug withdrawal and/or symptomatic management,and 6 patients died,indicating the potential risk of death.Conclusion Clinical workers should pay attention to the danger of adverse drug reactions caused by palbociclib,strengthen the monitoring of patients'medication,and ensure the safety of clinical medication.
palbociclibadverse reactionsliterature analysisvitiligo lesiondrug-induced pneumoniamacrocythemia and dysplastic anemia
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