Literature analysis of adverse drug reactions induced by lurasidone
Objective To analyze the clinical manifestations and characteristics of adverse drug reactions induced by lurasidone,and to provide reference for clinically safe drug use.Methods Case reports of adverse reactions caused by lurasidone from the establishment of the database to December 31,2023 were collected by searching CNKI,Wanfang Data,VIP,PubMed,Web of Science,and Embase databases for statistical analysis.Results 25 case reports were included with 35 patients.The ages of the patients were among 15—81 years old,with the average age of 46 years old.There was no significant difference between female(18 cases)and male(17 cases).The patients were from 7 countries.The United States accounted for the most(15 cases,42.9%).The dosage is between 20 to 160 mg.The most adverse drug reactions cases(27 cases,77.1%)occurred within 6 months.Organs/systems involved in adverse drug reactions were mainly nervous system disorders(13 cases,37.1%),followed by the psychiatric disorders(10 cases,28.6%),and the blood and lymphatic system disorders,endocrine disorders,cardiac disorders and metabolism and nutrition disorders.Among 35 patients,adverse drug reactions gradually diminished or disappeared in 32 patients after stopping lurasidone,adverse drug reactions was alleviated by reducing lurasidone dosage in 3 patients.Conclusion Lurasidone cause adverse drug reactions involving multiple organs/systems.Continuous pharmaceutical monitoring and follow-up should be carried out during drug use,especially in the first 6 months,so that timely measures can be taken when adverse drug reactions occurs to ensure the safety of clinical use of patients and reduce the risk of drug use.
lurasidoneadverse drug reactionliterature analysisnervous system disorderspsychiatric disorders
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