Fanconi anemia is a rare human genetic disease,often accompanied by susceptibility to cancer,bone marrow failure,and dysplasia.The proteins and related proteins encoded by the Fanconi anemia gene constitute the Fanconi anemia pathway.This pathway is involved in DNA damage repair and is closely related to tumor development,tumor resistance,and chemotherapy sensitization.This article summarizes the composition of the Fanconi anemia pathway and its involvement in DNA damage repair processes.It discusses the regulation of the Fanconi anemia pathway,and its impact on tumor drug resistance and chemotherapy sensitivity,and summarizes small molecule inhibitors targeting the Fanconi anemia pathway,which will provide new ideas for cancer intervention.
Fanconi anemia pathwayDNA damage repairtumor drug resistancechemotherapy sensitizationinhibitor
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