Research progress on mechanism of triptolide in prevention and treatment of ovarian cancer
Ovarian cancer is the second most common gynecological malignancy with a high mortality rate.Chemotherapy is the main treatment for ovarian cancer,but most patients will develop chemotherapy resistance.Tripterygiolide is a naturally active diterpenoid compound extracted from Tripterygii Wilfordii Radix et Rhizoma,with various pharmacological activities.Triptolide can play a multiple pathways to prevent and treat ovarian cancer by inhibiting tumor cell proliferation,promoting cell apoptosis,reducing invasiveness of ovarian cancer,reducing tumor cell resistance against cisplatin,regulating ovarian cancer cell cycle,enhancing anti-tumor immune response,and altering the tumor microenvironment.This article summarizes the mechanism of triptolide in prevention and treatment of ovarian cancer,providing a basis for the clinical treatment for ovarian cancer.
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