川芎嗪防治急性胰腺炎作用机制的研究进展
Research progress on mechanism of ligustrazine in prevention and treatment of acute pancreatitis
蒋怀春 1陈跃菊 1夏达建 1王苹1
作者信息
- 1. 重庆市大足区人民医院 急诊科,重庆 402360
- 折叠
摘要
急性胰腺炎具有发病迅速、并发症多、死亡率高等特点.川芎嗪可通过促进细胞凋亡、纠正微循环障碍、减轻炎症反应、减轻脂质过氧化反应、抑制脂多糖/Toll样受体4 信号通路、保护小肠黏膜屏障功能发挥防治急性胰腺炎的作用.归纳了川芎嗪防治急性胰腺炎的作用机制,为急性胰腺炎的治疗提供参考.
Abstract
Acute pancreatitis is characterized by fatal,pathogenic and high mortality.Ligustrazine can play a role in prevention and treatment of acute pancreatitis by promoting cell apoptosis,correcting microcirculation disorders,alleviating inflammatory reactions,reducing lipid peroxidation,inhibiting LPS/TLR4 signaling pathways,and protecting the intestinal mucosal barrier function.This article summarizes the mechanism of ligustrazine in prevention and treatment of acute pancreatitis,providing reference for the treatment of acute pancreatitis.
关键词
川芎嗪/急性胰腺炎/细胞凋亡/微循环障碍/炎症反应/脂质过氧化反应/小肠黏膜屏障功能Key words
ligustrazine/acute pancreatitis/cell apoptosis/microcirculation disorder/inflammatory reaction/lipid peroxidation/intestinal mucosal barrier function引用本文复制引用
基金项目
重庆市大足区科技发展项目(DZKJ-2021ACC1014)
出版年
2024
NETL
NSTL
万方数据