Pharmacokinetics of β-cyclodextrin-polyethyleneglycol-SN38 micelle in rat
Objective To study pharmacokinetics of β-cyclodextrin-polyethyleneglycol-SN38(β-CD-PEG-SN38)micelle in rat.Methods Contents of SN38 were determined by HPLC-MS/MS method,and a three-compartment model were used to estimate the pharmacokinetics parameters.Results After iv administered with β-CD-PEG-SN38 micelle,AUC of free type and bonded type SN38 was 1 490.7、5 060.3 ng/(mL·h),and the dominant SN38 in rat plasma was the bonded type.Conclusion This method is simple and practical to operate,and can provide reference for targeted drug delivery research of SN38.
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