Clinical study of Piantan Fuyuan Pills combined with clopidogrel in treatment of convalescent period of acute cerebral infarction
Objective To explore the therapeutic effect of Piantan Fuyuan Pills combined with clopidogrel in treatment of convalescent period of acute cerebral infarction.Methods 94 Patients with acute cerebral infarction admitted to Qinghai Red Cross Hospital from February 2021 to April 2023 were selected and divided into control group(47 cases)and treatment group(47 cases)according to random number table method.Patients in the control group were po administered with Clopidogrel Bisulfate Tablets,75 mg/time,once daily.Patients in the treatment group were po administered with Piantan Fuyuan Pills on the basis of the control group,1 pill/time,twice daily.Both groups were treated continuously for 4 weeks.The clinical efficacy of the two groups was observed,the TCM symptom score and serum inflammatory factor levels were compared before and after treatment,and the short-term prognosis and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the treatment group was 93.62%,which was significantly higher than that of the control group(78.72%,P<0.05).After treatment,the scores of dizziness,numbness of limbs,dull tongue,and shortness of breath in both groups were significantly lower than before treatment(P<0.05),and the scores of TCM symptoms in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of serum C-reactive protein(CRP),monocyte chemoattractant protein-1(MCP-1),and interleukin-6(IL-6)in both groups were significantly decreased compared with those before treatment(P<0.05),and after treatment,the levels of serum CRP,MCP-1,and IL-6 in the treatment group were significantly improved(P<0.05).The good short-term prognosis rate in the treatment group was 82.98%,which was significantly higher than that in the control group(63.83%)(P<0.05).After treatment,the incidence of adverse reactions was 6.38%in the treatment group and 2.13%in the control group.There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Piantan Fuyuan Pills combined with clopidogrel has a good therapeutic effect in treatment of convalescent period of acute cerebral infarction,and can effectively improve TCM symptoms,inflammatory state and short-term prognosis with low incidence of adverse reactions and mild symptoms.
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