Clinical study on Yindan Xinnaotong Soft Capsules combined with duplex antiplatelet regimen in treatment of acute cerebral infarction
Objective To explore the clinical effect of Yindan Xinnaotong Soft Capsules combined with duplex antiplatelet regimen in treatment of acute cerebral infarction.Methods Patients(100 cases)with acute cerebral infarction in Peking University Shougang Hospital from January 2020 to January 2022 were divided into control(50 cases)and treatment(50 cases)group according to random number table method.Patients in the control group were po administered with Aspirin Enteric-coated Tablets,100 mg/time,once daily,and they were po administered with Clopidogrel Hydrogen Sulphate Tablets,75 mg/time,once daily.Patients in the treatment group were po administered with Yindan Xinnaotong Soft Capsules on the basis of the control group,3 grains/time,three times daily.Patients in two groups were treated for 2 weeks.After treatment,the clinical evaluations were evaluated,the scores of NIHSS and Barthel index,and the levels of LPO,MDA,miR-449a and miR-19b-3p in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was significantly higher than that of the control group(96.00%vs 84.00%,P<0.05).After treatment,the NIHSS score in two groups was significantly lower than that before treatment,while the score of Barthel index was significantly higher(P<0.05),and which in the treatment group were significantly better than those in the control group(P<0.05).After treatment,the levels of LPO and MDA and the expression of miR-19b-3p in two groups were significantly lower than those before treatment(P<0.05),while the expression level of miR-449a in the treatment group was significantly higher(P<0.05),and the level of these indexes in the treatment group was significantly better than that in the control group(P<0.05).Conclusion Yindan Xinnaotong Soft Capsules combined with duplex antiplatelet regimen has high efficacy and safety in patients with acute cerebral infarction after interventional operation,which is helpful to regulate the expression of miR-449a and miR-19b-3p,reduce the level of oxidative stress and neurological impairment,and improve the ability of daily living.
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