Clinical study on Xinshubao Tablets combined with nicorandil in treatment of angina pectoris of coronary heart disease
Objective To observe the clinical effect of Xinshubao Tablets combined with Nicorandil Tablets in treatment of angina pectoris of coronary heart disease.Methods Patients(136 cases)with angina pectoris of coronary heart disease in the First Affiliated Hospital of Zhengzhou University from June 2021 to June 2022 were divided into control and treatment groups according to the bicolor sphere method,and each group had 68 cases.Patients in the control group were po administered with Nicorandil Tablets,5 mg/time,three times daily.Patients in the treatment group were po administered with Xinshubao Tablets after meals on the basis of the control group,1—2 tablets/time,twice daily.Patients in two groups were treated for 3 months.The clinical efficacies,the clinical symptoms,cardiac function indicators,hemorheological indicators,and oxidative stress indicators in two groups were compared.Results After treatment,the total effective rate of the treatment group(94.12%)was significantly higher than76.47%of the control group(P<0.05).After treatment,the frequency of angina pectoris attacks,the duration of angina pectoris attacks,and the daily dosage of nitroglycerin were decreased,CO,LVEF,and CI were significantly increased,the plasma viscosity,whole blood high tangential viscosity,and whole blood low tangential viscosity were decreased,the serum level of SOD increased,but the serum level of MDA decreased in two groups(P<0.05),and the improvement of clinical indexes in the treatment group was better than those in the control group(P<0.05).Conclusion Xinshubao Tablets combined with Nicorandil Tablets in the treatment of angina pectoris of coronary heart disease has a good improvement effect in treatment of angina pectoris,can significantly improve angina symptoms,hemorheology,and alleviate oxidative stress symptoms.
Xinshubao TabletsNicorandil Tabletsangina pectoris of coronary heart diseasefrequencydurationdaily dosage of nitroglycerinCOLVEFCIplasma viscositywhole blood low tangential viscositySODMDA
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