Clinical study of Shuanghuanglian Injection combined with piperacillin sodium and tazobactam sodium in treatment of community acquired pneumonia
Objective To explore the clinical efficacy of Shuanghuanglian Injection combined with piperacillin sodium and tazobactam sodium in treatment of community acquired pneumonia.Methods A total of 86 patients with community-acquired pneumonia admitted to Fengfeng General Hospital of North China Medical and Health Group from October 2020 to September 2023 were selected and divided into control group and treatment group according to random number table method,with 43 cases in each group.Patients in the control group were iv administered with Piperacillin Sodium and Tazobactam Sodium for injection,after fully dissolving 4.5 g of the product with diluent,immediately added it into 5%glucose injection100 mL,each administration time≥30 min,twice daily.Patients in the treatment group were iv administered with Shuanghuanglian Injection on the basis of the control group,added 5%glucose injection250 mL at the weight of 1 mL/kg,once daily.The treatment course of both groups was 7 d.The clinical effects of the two groups were observed,and the disappearance time of clinical manifestations,oxygenation index(OI),CURB-65 score,erythrocyte settlement rate(ESR),neutrophil to lymphocyte ratio(NLR),serum amyloid A(SAA)and procalcitonin(PCT)were compared between two groups.Results After treatment,the total effective rate of the treatment group was 97.67%,which was significantly higher than that of control group(81.40%,P<0.05).The disappearance time of fever,cough,phlegm,chest pain,and lung rales in treatment group was significantly shorter than that in control group(P<0.05).After treatment,OI was significantly increased in both groups,but CURB-65 score was significantly decreased in both groups(P<0.05).After treatment,OI in treatment group was significantly higher than that in control group,but CURB-65 score was significantly lower than that in control group(P<0.05).After treatment,the levels of ESR,NLR and serum SAA and PCT in both groups were significantly decreased(P<0.05).After treatment,the levels of ESR,NLR,SAA,and PCT in the treatment group were lower than those in control group(P<0.05).Conclusion Shuanghuanglian Injection combined with piperacillin sodium and tazobactam sodium has a definite effect in treatment of community acquired pneumonia,and can effectively promote the elimination of clinical manifestations and the improvement of respiratory function,inhibit the inflammatory state of the body and the degree of lung infection,and help accelerate the remission of the disease,which is worthy of clinical promotion and application.
Shuanghuanglian InjectionPiperacillin Sodium and Tazobactam Sodium for injectioncommunity acquired pneumoniaOISAAPCT
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