Objective To explore the clinical effect of carbocisteine combined with procaterol in treatment of bronchial asthma in children.Methods A total of 80 children with bronchial asthma admitted to the Department of Pediatrics of Tianjin Union Medical Center from June 2021 to July 2023 were selected and divided into control group and treatment group according to different treatment methods,with 40 cases in each group.Patients in the control group were po administered with Procaterol Hydrochloride Oral Solution,3 mL/time,once daily.Patients in the treatment group were po administered with Carbocisteine Tablets on the basis of the control group,0.5 tablet/time,three times daily.Both groups were treated continuously for 7 d.The clinical efficacy and symptom resolution time of two groups were observed,and the scores of childhood Asthma Control test(C-ACT)and serum inflammatory factors before and after treatment were compared.Results After treatment,the total effective rate of the treatment group was 95.08%,which was significantly higher than that of control group(77.50%,P<0.05).After treatment,the disappearance time of wheezing,phlegm chirping,cough,and wheezing in treatment group was significantly shorter than that in control group(P<0.05).After treatment,C-ACT scores in 2 groups were significantly higher than before treatment(P<0.05).After treatment,the C-ACT score of treatment group was significantly higher than that of control group(P<0.05).After treatment,the levels of interferon-γ(INF-γ)in two groups were significantly higher than before treatment,but the levels of interleukin-6(IL-6),intercellular adhesion factor-1(ICAM-1),and leukotriene B4(LTB4)were significantly decreased(P<0.05).After treatment,serological indexes in treatment group were better than those in control group(P<0.05).Conclusion Carbocisteine combined with procaterol has good clinical efficacy in treatment of bronchial asthma in children,and can effectively improve the clinical symptoms of children,regulate the serum inflammatory factors with good safety and effect,which is worthy of clinical application.
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