Clinical study of Shuanghuanglian Oral Liquid combined with Xiyanping Injection in treatment of herpetic angina in children
Objective To explore the efficacy of Shuanghuanglian Oral Liquid combined with Xiyanping Injection in treatment of herpetic angina in children.Methods A total of 120 children with herpetic angina treated in Chengdu Longquanyi District Maternal and Child Health Hospital from September 2022 to August 2023 were selected and divided into control group and treatment group by random number table method,with 60 cases in each group.Patients in the control group were iv administered with Xiyanping Injection,0.4 mL/kg was mixed with normal saline and then injected intravenously,the maximum dosage was not more than 20 mL,once daily.Patients in the treatment group were po administered with Shuanghuanglian Oral Liquid on the basis of control group,1≤children age<3 years old,10 mL/time;3≤children nage<7 years old,20 mL/time,3 times daily.Both groups were treated continuously for 5 d.The clinical efficacy,temperature to normal range time,throat pain disappearance time of two groups were observed,and the ratio of neutrophil to lymphocyte(NLR),serum C-reactive protein(CRP),and tumor necrosis faction-α(TNF-α)before and after treatment were compared between the two groups.Results After treatment,the total effective rate of treatment group was 96.67%,which was significantly higher than that of control group(86.67%,P<0.05).After treatment,the temperature to normal range and the disappearance time of pharyngeal pain in treatment group were significantly shorter than those in control group(P<0.05).After treatment,the levels of NLR and serum CRP and TNF-α in 2 groups were significantly decreased compared with those before treatment(P<0.05).After treatment,the levels of NLR,serum CRP and TNF-α in treatment group were lower than those in control group(P<0.05).Conclusion Shuanghuanglian Oral Liquid combined with Xiyanping Injection can obtain ideal curative effect in treatment of herpetic angina in children,and can quickly improve the symptoms of abnormal temperature rise and sore throat in children,and has obvious inhibitory effect on inflammation in the body,which has no obvious adverse reactions.
Shuanghuanglian Oral LiquidXiyanping Injectionherpetic anginatemperature to normal range timetime of disappearance of sore throatNLRCRPTNF-α
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