Clinical study of Xiaoer Resuqing Oral Liquid combined with cefotaxime in treatment of acute upper respiratory tract infection in children
Objective To explore the clinical efficacy of Xiaoer Resuqing Oral Liquid combined with cefotaxime in treatment of acute upper respiratory tract infection in children.Methods A total of 84 children with acute upper respiratory tract infection admitted to Tongling Maternal and Child Health Hospital from January 2020 to December 2022 were selected and divided into control group and treatment group according to random number table method,with 42 cases in each group.Patients in the control group were iv administered with Cefotaxime Sodium for injection,50 mg/kg was added into 0.9%sodium chloride injection 100 mL,twice daily.Patients in the treatment group were po administered with Xiaoer Resuqing Oral Liquid on the basis of control group,1 to 3 years old 10 mL/time,3 to 7 years old 15 mL/time,7 to 12 years old 20 mL/time,3 times daily.The treatment course of both groups was 4 d.The antipyretic effect and the disappearance time of clinical symptoms in two groups were observed,a nd the levels of whole blood lymphocyte to monocyte ratio(LMR),neutrophil to lymphocyte ratio(NLR),hypersensitive C-reactive protein(hs-CRP)and serum procalcitonin(PCT)were compared before and after treatment.Results After treatment,the total effective rate of treatment group was 95.24%,which was significantly higher than that of control group(80.95%,P<0.05).After treatment,the temperature recovery time and antipyretic onset time of treatment group were significantly shorter than those of control group,and the immediate antipyretic rate of treatment group was significantly higher than that of control group(P<0.05).After treatment,the disappearance time of nasal congestion,runny nose,cough and sore throat in treatment group was significantly shorter than that in control group(P<0.05).After treatment,whole blood LMR levels were significantly increased in both groups,but whole blood NLR,hs-CRP and serum PCT levels were significantly decreased(P<0.05).After treatment,whole blood LMR,NLR,hs-CRP and serum PCT levels in treatment group were better than those in control group(P<0.05).Conclusion Xiaoer Resuqing Oral Liquid combined with cefotaxime has good clinical efficacy in treatment of acute upper respiratory tract infection in children,and can effectively shorten the recovery time of symptoms and signs in children,inhibit the inflammatory state of the body with good safety,which is worthy of clinical application.
Xiaoer Resuqing Oral LiquidCefotaxime Sodium for injectionacute upper respiratory tract infectiontime of clinical symptoms disappearLMRNLRhs-CRP
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