Clinical study on Wang's Baochi Pills combined with Combined Clostridium Butyricum and Bifidobacterium Powders in treatment of infantile milk protein allergic diarrhea
Objective To explore the clinical effect of Wang's Baochi Pills combined with Combined Clostridium Butyricum and Bifidobacterium Powders in treatment of infantile milk protein allergic diarrhea.Methods A total of 112 infants with milk protein allergic diarrhea treated in Children's Hospital Affiliated to Zhengzhou University from September 2021 to October 2023 were selected retrospectively,and they were divided into control group(56 cases)and treatment group(56 cases)according to the different treatment methods.Patients in the control group were po administered with Combined Clostridium Butyricum and Bifidobacterium Powders,1 bag/time,twice daily.Patients in the treatment group were po administered with Wang's Baochi Pills on the basis of the control group,6 pills/time,once daily.Patients in two groups were treated for 7 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,IgE,EOS,and fecal EOS,and the levels of serum TGF-β,TNF-α,IL-6 and INF-γ in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 94.64%,which was significantly higher than that of the control group(83.93%,P<0.05).After treatment,the time of symptom relief in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the counts of EOS,IgE and fecal EOS in two groups were significantly lower than those before treatment,and which in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the serum levels of TGF-β,TNF-α and IL-6 in two groups were significantly lower than those before treatment,but the level of INF-γwas significantly increased(P<0.05),and the level of serology in the treatment group was significantly better than that in the control group(P<0.05).Conclusion The combined treatment of Combined Clostridium Butyricum and Bifidobacterium Powders and Wangshi Baochi Pills can significantly relieve the symptoms of diarrhea,significantly improve the immune ability of children,and weaken the state of inflammatory reaction.
Wang's Baochi PillsCombined Clostridium Butyricum and Bifidobacterium Powders,Liveinfantile milk protein allergic diarrheaEOSTNF-αTGF-β
NETL
NSTL
万方数据
