Clinical study of Jieshitong Capsules combined with ampicillin in treatment of urinary tract infection
Objective To explore the clinical efficacy of Jieshitong Capsules combined with ampicillin in treatment of urinary tract infection.Methods A total of 86 patients with urinary tract infection admitted to Bengbu First People's Hospital from July 2020 to June 2023 were selected and divided into control group and treatment group according to random number table method,with 43 cases in each group.Patients in the control group were po administered with Ampicillin Capsules,3 grains/time,three times daily.Patients in the treatment group were po administered with Jieshitong Capsules on the basis of control group,4 grains/time,3 times daily.The treatment course of both groups was 7 d.After treatment,the clinical efficacy was evaluated,and the time for fever reduction,the time for urine bacterial culture to turn negative,and the typical symptom scores before and after treatment,as well as the scores of 36 health survey questionnaires(SF-36)and serum C-reactive protein(CRP),procalcitonin(PCT),and interleukin-6(IL-6)levels were compared.Results After treatment,the total effective rate of the treatment group was 97.67%,which was significantly higher than that of the control group(81.40%)(P<0.05).After treatment,the scores of urinalgia,frequency of urination,urgency of urination,and lower abdominal discomfort in 2 groups were significantly lower than before treatment(P<0.05).After treatment,the typical symptom score of the treatment group was lower than that of control group(P<0.05).The time of febrile degeneration and the time of urine bacterial culture turning negative in treatment group were significantly shorter than those in control group(P<0.05).After treatment,SF-36 scores in both groups were significantly increased,but serum CRP,PCT,and IL-6 levels were significantly decreased(P<0.05).After treatment,the SF-36 score of treatment group was higher than that of control group,but the levels of serum CRP,PCT and IL-6 were lower than those of the control group(P<0.05).Conclusion Jieshitong Capsules combined with ampicillin has the exact effect in treatment of urinary tract infection,and can significantly improve the life quality,and can effectively control the symptoms of urinary tract infection,shorten the time of urinary bacterial culture to negative,relieve the body inflammatory response,which is worthy of clinical application.
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