Objective To explore the therapeutic effect of Yishen Huashi Granules and Bumetanide Tablets in treatment of chronic glomerulonephritis.Method Patients(120 cases)with chronic glomerulonephritis in Liyang People's Hospital from May 2020 to April 2023 were divided into control and treatment groups according to the computer random arrangement method,and each group had 60 cases.Patients in the control group were po administered with Bumetanide Tablets,2 tablets/time,three times daily.Patients in the treatment group were po administered with Yishen Huashi Granules on the basis of the control group,1 bag/time,three times daily.Patients in two groups were treated for 3 months.After treatment,the clinical efficacies were evaluated,and the symptom improvement,renal function,and serum markers in two groups were compared.Results The total effective rate of the treatment group(91.67%)was significantly higher than 78.33%of the control group,with significant difference between groups(P<0.05).After treatment,the disappearance time of edema,hematuria,and proteinuria in the treatment group was shorter than that in the control group(P<0.05).After treatment,the levels of GFR in two groups were higher than before treatment,but the levels of Scr,Cys-C,and UAER were lower than before treatment(P<0.05).The levels of GFR in the treatment group were higher than that in the control group,but the levels of Scr,Cys-C,and UAER in the treatment group were higher than those in the control group(P<0.05).After treatment,the serum levels of NGAL,MCP-1,and Lkn-1 in two groups were lower than before treatment(P<0.05),and the serum levels of NGAL,MCP-1,and Lkn-1 in the treatment group were lower than those in the control group(P<0.05).Conclusion Yishen Huashi Granules and Bumetanide Tablets in treatment of chronic glomerulonephritis can improve the clinical efficacy of chronic glomerulonephritis,significantly reduce clinical symptoms,improve renal function,and reduce the damage of renal tissue inflammation.
Yishen Huashi GranulesBumetanide Tabletschronic glomerulonephritisdisappearance time of proteinuriaGFRUAERMCP-1Lkn-1
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