Clinical study on Hulisan Capsules combined with diacerein in treatment of knee osteoarthritis
Objective To investigate the therapeutic effect of Hulisan Capsules combined with Diacerein Capsules in treatment of knee osteoarthritis.Methods Patients(104 cases)with knee osteoarthritis in Tangshan People's Hospital from February 2021 to January 2023 were divided into control group(52 case)and treatment group(52 case)according to the random number table method.Patients in the control group were po administered with Diacerein Capsules,1 grain/time,twice daily.Patients in the treatment group were po administered with Hulisan Capsules on the basis of the control group,1 grain/time,twice daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical efficacies,symptoms on the affected side,joint function,and serum indicators in two groups were compared.Results After treatment,the total effective rate was 92.31%in the treatment group,and 76.92%in the control group,and the difference between the two groups was significant(P<0.05).After treatment,the NRS score,morning rigor time,the WOMAC score,and the serum levels of TSP-1,IL-15,and GPI of two groups were lower than before treatment(P<0.05),and the indexes of the treatment group were lower than those of the control group(P<0.05).Conclusion The clinical efficacy of treating knee osteoarthritis with the combination of Hulisan Capsules and Diacerein Capsules has been further improved,the patient's clinical symptoms have significantly alleviated,knee joint function has significantly improved,and inflammatory damage has been alleviated.
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