Clinical study on Zhuanggu Guanjie Pills combined with etoricoxib in treatment of early knee osteoarthritis
Objective To explore the clinical efficacy of Zhuanggu Guanjie Pills combined with etoricoxib in treatment of early knee osteoarthritis.Methods Patients(84 cases)with early knee osteoarthritis in Shanxi Province Fenyang Hospital from May 2020 to May 2023 were divided into control(42 cases)and treatment(42 cases)group according to random number table method.Patients in the control group were po administered with Etoricoxib Tablets,the initial dose was 30 mg/time,and if there was no obvious relief after 2 weeks,the dose was adjusted to 60 mg/times,once daily.Patients in the treatment group were po administered with Zhuanggu Guanjie Pills on the basis of the control group,6 g/time,twice daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical evaluations were evaluated,the symptom relief time,the scores VAS,Lysholm and SF-36,and the levels of serum IL-6,TNF-α and hs-CRP in two groups before and after treatment were compared.Results After treatment,the total clinical effective rate of the treatment group was 95.24%,which was significantly higher than that of the control group(80.95%,P<0.05).After treatment,the VAS scores in two groups were significantly decreased,while the Lysholm scores were significantly increased(P<0.05),and the scores in the treatment group were significantly better than those of the control group(P<0.05).After treatment,the serum levels of IL-6,TNF-α and hs-CRP in two groups were significantly decreased(P<0.05),and the decrease of serum level in the treatment group was significantly higher than that in the control group(P<0.05).After treatment,SF-36 scores in each dimension of two groups were significantly increased(P<0.05),and the scores of general health,somatic pain,vital vitality,and physiological function in the treatment group were significantly better than those of the control group(P<0.05).Conclusion Zhuanggu Guanjie Pills combined with etoricoxib has a good therapeutic effect in the treatment of early knee osteoarthritis,which can reduce knee joint pain,improve knee joint function,inflammatory state and quality of life.
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