骨康胶囊联合骨肽片治疗桡骨远端骨折的临床研究
Clinical study on Gukang Capsules combined with Ossotide Tablets in treatment of distal radial fractures
张小龙 1徐露 1秦夏冰 1姚忠军1
作者信息
- 1. 十堰市太和医院 骨二科,湖北 十堰 442000
- 折叠
摘要
目的 探讨骨康胶囊联合骨肽片治疗桡骨远端骨折的临床疗效.方法 选取十堰市太和医院在 2021 年 6 月—2023年 5 月收治的桡骨远端骨折患者 100 例,按计算机随机法将100 例患者分为对照组(50 例)和治疗组(50 例).对照组患者口服骨肽片,2 片/次,3 次/d.治疗组在对照组治疗的基础上口服骨康胶囊,4 粒/次,3 次/d.15 d为 1 个疗程,持续治疗3个疗程.比较两组的临床疗效、恢复情况、症状情况和血清指标.结果 治疗后,治疗组的总有效率高于对照组,差异有统计学意义(96.00%vs 82.00%,P＜0.05).治疗后,治疗组疼痛消失时间、肿胀消失时间和骨折愈合时间均比对照组短,差异有统计学意义(P＜0.05).治疗后,两组疼痛评分、功能状况评分、活动范围评分、握力评分,血清骨碱性磷酸酶(BALP)、骨钙素(BGP)水平比治疗前高,血清Ⅰ型胶原羧基端肽β特殊序列(β-CTX)水平比治疗前低(P＜0.05);治疗组的症状情况和血清指标均好于对照组(P＜0.05).结论 骨康胶囊联合骨肽片可提高桡骨远端骨折的疗效,促进骨折愈合,减轻临床症状,调节骨代谢.
Abstract
Objective To explore the clinical efficacy of Gukang Capsules combined with Ossotide Tablets in treatment of distal radial fractures.Methods Patients(100 cases)with distal radial fractures in Shiyan Taihe Hospital from June 2021 to May 2023 were divided into control and treatment groups according to computer randomization method,with each group 50 cases.Patients in the control group were po administered with Ossotide Tablets,2 tablets/time,three times daily.Patients in the treatment group were po administered with Gukang Capsules on the basis of the control group,4 grains/time,three times daily.One course was 15 d,and three courses were carried out.After treatment,the clinical efficacies,the recovery situation,symptom status,and serum indicators in two groups were compared.Results After treatment,the total effective rate of the treatment group was higher than that of the control group(96.00%vs 82.00%,P<0.05).After treatment,the pain disappearance time,swelling disappearance time,and fracture healing time in the treatment group were shorter than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of pain,functional status,range of motion,and grip strength,and the serum levels of BALP and BGP in two groups were increased,but the serum levels of β-CTX in two groups were decreased(P<0.05).The symptom status,and serum indicators in the treatment group were better than those in the control group(P<0.05).Conclusion Gukang Capsules combined with Ossotide Tablets can improve the curative effect of distal radius fracture,promote fracture healing,reduce clinical symptoms,and regulate bone metabolism.
关键词
骨康胶囊/骨肽片/桡骨远端骨折/疼痛消失时间/骨折愈合时间/握力评分/骨碱性磷酸酶/骨钙素/Ⅰ型胶原羧基端肽β特殊序列Key words
Gukang Capsules/Ossotide Tablets/distal radius fracture/disappearance time of pain/fracture healing time/score of grip strength/BALP/BGP/CTX-Ⅰ引用本文复制引用
基金项目
十堰市引导性科研项目(22Y36)
十堰市引导性科研项目(22Y37)
出版年
2024
NETL
NSTL
万方数据