Clinical study on Mudan Granules combined with levocarnitine in treatment of diabetic peripheral neuropathy
Objective To explore the clinical effect of Mudan Granules combined with levocarnitine in treatment of peripheral neuropathy.Methods Patients(116 cases)with peripheral neuropathy in Eighth People's Hospital of Hebei Province from August 2021 to August 2023 were randomly divided into control(58 cases)and treatment(58 cases)group.Patients in the control group were po administered with Levocarnitine Oral Solution,20 mL/time,three times daily.Patients in the treatment group were po administered with Mudan Granules on the basis of the control group,1 bag/time,three times daily.Patients in two groups were treated for 28 d.After treatment,the clinical evaluations were evaluated,symptom relief time,TCSS scores,the levels of ficolin-3,NSE,Hcy and IGF-1 in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 98.28%,which was significantly higher than that of the control group(82.75%,P<0.05).After treatment,the TCSS score in two groups was significantly decreased(P<0.05),and the TCSS score of the treatment group was decreased more significantly than that of the control group(P<0.05).After treatment,the levels of NSE and Hcy were significantly decreased,while the levels of ficolin-3 and IGF-1 were significantly higher in two groups(P<0.05),and the levels of these indicators in the treatment group were significantly better than that in the control group(P<0.05).Conclusion The synergistic treatment of levocarnitine and Mudan Granules can effectively improve the pathological changes of peripheral nerve endings and promote the weakening of systemic inflammatory response.
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