Clinical observation of Qianggan Capsules combined with compound diisopropylamine dichloroacetate in treatment of chronic hepatitis B
Objective To explore the clinical effect of Qianggan capsule combined with compound diisopropylamine dichloroacetate in treatment of chronic hepatitis B.Methods Clinical data of 100 patients with chronic hepatitis B admitted to the Department of Gastroenterology of the First Affiliated Hospital of Henan University of Chinese Medicine from June 2021 to June 2023 were retrospectively analyzed.The patients were divided into control group and treatment group according to different treatment methods,with 50 cases in each group.Patients in the control group were iv administered with Compound Diisopropylamine Dichloroacetate Injection,40 mg/time,diluted with 0.9%sodium chloride solution 100 mL,once daily.Patients in the treatment group were po administered with Qianggan Capsules on the basis of the control group,3 grains/time,3 times daily.Both groups were treated continuously for 30 d.The clinical efficacy and duration of clinical symptom remission were observed,and the changes of liver function indexes and serum inflammatory factors before and after treatment were compared between the two groups.Results After treatment,the total effective rate of the treatment group was 98.00%,which was significantly higher than that of the control group(82.00%,P<0.05).After treatment,the time of fatigue,abdominal distension,fear of eating and relief of liver pain in the treatment group were shorter than those in the control group(P<0.05).After treatment,total bilirubin(TBil),alanine aminotransferase(ALT),and aspartate aminotransferase(AST)in 2 groups were significantly decreased compared with before treatment(P<0.05).After treatment,the liver function index of the treatment group was significantly lower than that of the control group(P<0.05).After treatment,the levels of interleukin17(IL-17),transforming growth factor β1(TGF-β1)and matrix metalloproteinase-1(TIMP-1)in 2 groups were significantly lower than before treatment,while the levels of interferon-γ(INF-γ)were higher than before treatment(P<0.05).After treatment,the improvement of serological indexes in treatment group was better than that in control group(P<0.05).Conclusion Qianggan Capsule combined with compound diisopropylamine has accurate effect in treatment of chronic hepatitis B,and can accelerate the effective relief of clinical symptoms,promote the effective improvement of liver function,weaken the local inflammatory response of the body,which is worthy of clinical application.
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