Literature analysis of adverse drug reactions induced by gilteritinib
Objective To analyze the clinical characteristics of adverse drug reaction induced by gilteritinib,so as to provide reference for clinical safe and rational drug use.Methods Searching the case reports or studies in CNKI,VIP,Wanfang,PubMed,and Embase,the adverse drug reaction cases related to gilteritinib were statistical analyzed.Results A total of 13 literatures involving 20 patients were enrolled in our study,including 7 males(35%)and 13 females(65%).The majority of patients were over 50 years old(14 cases,70%)and the primary disease was relapsed or refractory acute myeloid leukemia(19 cases,95%).Most adverse drug reaction occurred within 2 months(16 cases,80%),mainly involving nervous system(25%),gastrointestinal system(17.5%)and skin system(17.5%).Severe acute kidney injury,immune-related enteritis,and intracranial hemorrhage were the new adverse drug reaction.Most patients were improved after receiving symptomatic treatment,but 2 patients died of complications after intracranial hemorrhage.Conclusion The prevention of adverse drug reaction related to gilteritinib should be strengthened,so as to ensure the safety of patients.
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