Adverse reactions of cardiovascular system induced by quetiapine in Beijing Anding Hospital Affiliated to Capital Medical University from 2014 to 2023
Objective To investigate and analyze the characteristics of adverse drug reactions in cardiovascular system caused by quetiapine in Beijing Anding Hospital Affiliated to Capital Medical University.Methods 121 Cases of adverse cardiovascular reactions caused by quetiapine reported to the National Adverse Reaction Center in Beijing Anding Hospital Affiliated to Capital Medical University from 2014 to 2023 were selected and analyzed.Adverse reactions,drug treatment,treatment measures and outcomes of patients were analyzed in detail,and the clinical characteristics of adverse cardiovascular reactions caused by quetiapine were discussed.Results Among the 121 patients,women accounted for a large proportion(61.98%).The primary disease was bipolar disorder,51 cases(42.15%).When adverse reactions occurred,the dosage was low,and only 12 patients had a dose of more than 700 mg/d.Orthostatic hypotension accounted for a large proportion(42.98%).Most of the adverse reactions occurred in the early stage of medication,and most of the adverse reactions appeared within 10 d of medication.In terms of clinical manifestations of adverse reactions,systolic and diastolic blood pressure were reduced in patients with orthostatic hypotension to varying degrees.After adverse reactions occurred,patients were treated in time and adverse reactions conditions were closely observed,and symptoms were relieved or returned to normal.Conclusions Quetiapine is still at risk of cardiovascular adverse events at smaller daily doses.Quetiapine can also cause rare adverse reactions,including palpitations,hypertension,QT interval prolongation,bradycardia,etc.QT interval prolongation is a more serious adverse reaction,which may lead to more serious adverse reactions,such as sudden cardiac death.For the presence of congenital long QT syndrome,heart failure,female,elderly and other risk factors,it is necessary to do a comprehensive examination during the use of quetiapine,in the early stage of drug treatment,electrolyte and electrocardiogram monitoring should be carried out to avoid more serious adverse reactions.
quetiapinecardiovascular systemadverse drug reactionrational use of drugsorthostatic hypotensionoalpitationQT interval prolongation
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