首页|氧化苦参碱治疗过敏性皮肤病作用机制的研究进展

氧化苦参碱治疗过敏性皮肤病作用机制的研究进展

Research progress on mechanism of oxymatrine in treatment of allergic skin diseases

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过敏性皮肤病具有慢性、复发性特点,需长期接受药物治疗,但可引起不同程度不良反应,且停药后症状易复发.氧化苦参碱是苦参、槐花中主要活性成分,通过抑制肥大细胞活化、调节淋巴细胞增殖、调节Th1/Th2 的平衡、调节辅助T细胞 17/调节T细胞平衡、调节细胞因子信号传导抑制因子 1 的表达、下调瞬时受体电位通道蛋白A1 和瞬时受体电位通道蛋白V1 的表达、抑制丝裂原活化蛋白激酶/蛋白激酶B信号通路激活多途径多靶点防治过敏性皮肤病.综述了氧化苦参碱治疗过敏性皮肤病的作用机制,为氧化苦参碱的临床使用提供依据.
Allergic skin diseases have chronic and recurrent characteristics,and patients need long-term treatment,but can cause varying degrees of adverse reactions,and symptoms are prone to recurrence after discontinuation of medication.Oxymatrine is the main active ingredient in Sophorae Flavescentis Radix and Sophorae Flos.Oxymatrine can prevent and treat allergic skin diseases through multiple pathways and targets through inhibiting mast cell activation,regulating lymphocyte proliferation,regulating Th1/Th2 balance,regulating Th17/Treg balance,regulating the expression of cytokine signaling inhibitory factor 1,down-regulating the expression of TRPA1 and TRPV1,and inhibiting the activation of MAPK/Akt signaling pathway.This article reviews the mechanism of action of oxymatrine in treatment of allergic skin diseases,providing a basis for the clinical use of oxymatrine.

oxymatrineallergic skin diseasemast cell activationlymphocyte proliferationTh1/Th2cytokine signaling inhibitory factor 1MAPK/Akt signaling pathway

韦汝静、蔡川川、李芳谷、叶巧园

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广东医科大学附属医院 皮肤性病科,广东 湛江 524000

广东医科大学,广东 湛江 524000

氧化苦参碱 过敏性皮肤病 肥大细胞活化 淋巴细胞增殖 Th1/Th2 细胞因子信号传导抑制因子1 丝裂原活化蛋白激酶/蛋白激酶B信号通路

广东省普通高校特色创新类项目

2023KTSCX041

2024

10.7501/j.issn.1674-5515.2024.04.045

现代药物与临床
天津药物研究院,中国药学会

现代药物与临床

CSTPCD
影响因子：1.179
ISSN：1674-5515
年,卷(期)：2024.39(4)
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