首页|HPLC多指标成分定量结合化学计量学、加权TOPSIS模型评价不同产地肺形草质量

HPLC多指标成分定量结合化学计量学、加权TOPSIS模型评价不同产地肺形草质量

Evaluation of Tripterospermum chinense from different origins by HPLC multi index component combined with chemometrics and weighted TOPSIS model

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目的 评价不同产地肺形草的质量差异.方法 采用HPLC法测定肺形草中马钱苷酸、莫诺苷、獐牙菜苦苷、龙胆苦苷、芒果苷、异荭草苷、异牡荆素、去甲基雏菊叶龙胆酮、当药黄素、3,6,8-三羟基-1-甲基呫吨酮、山楂酸和熊果酸,对多指标成分测定结果进行主成分分析、正交偏最小二乘法-判别分析,建立加权优劣解距离模型评估.结果 16 批肺形草明显聚集为 3 类;马钱苷酸、莫诺苷、3,6,8-三羟基-1-甲基呫吨酮、熊果酸、当药黄素和芒果苷是影响肺形草质量的主要潜在标志物;浙江和江苏产肺形草整体质量较好.结论 建立的方法控制模式简单、评价模型科学合理,可用于肺形草质量评价.
Objective To evaluate the quality difference of Tripterospermum chinense from different origins.Methods Contents of loganic acid,morroniside,swertiamain,gentiopicrin,mangiferin,isoorientin,isovitexin,demethylbellidifolin,swertisin,3,6,8-trihydroxy-1-methyl-xanthen-9-one,maslinic acid and ursolic acid in T.chinense were determined by HPLC method.PCA and OPLS-DA were used to analyze the contents of multi-component components,and the weighted-TOPSIS model was established to evaluate the quality.Results 16 Batches of T.chinense were clustered into three categories,and loganic acid,morroniside,3,6,8-trihydroxy-1-methyl-xanthen-9-one,ursolic acid,swertisin,and mangiferin were the main potential markers affecting the quality of T.chinense.The overall quality of T.chinense from Zhejiang and Jiangsu Provinces is good.Conclusion The established method has a simple control mode and a scientifically reasonable evaluation model,which can be used for the quality evaluation of T.chinense.

Tripterospermum chinense(Migo)H.Smithloganic acidmorronisideswertiamaingentiopicrinmangiferinisoorientinisovitexindemethylbellidifolinswertisin3,6,8-trihydroxy-1-methyl-xanthen-9-onemaslinic acidursolic acidHPLCPCAOPLS-DAweighted-TOPSIS mod

张立群、马诗瑜、冯恺、徐虹

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上海交通大学医学院附属瑞金医院 药剂科,上海 200025

上海中医药大学,上海 200032

肺形草 钱苷酸 莫诺苷 獐牙菜苦苷 龙胆苦苷 芒果苷 异荭草苷 异牡荆素 去甲基雏菊叶龙胆酮 当药黄素 3,6,8-三羟基-1-甲基呫吨酮 山楂酸 熊果酸 高效液相色谱 主成分分析 正交偏最小二乘法-判别分析 加权优劣解距离模型

上海市"医苑新星"青年医学人才培养资助计划

沪卫人事[2022]65号

2024

现代药物与临床
天津药物研究院,中国药学会

现代药物与临床

CSTPCD
影响因子:1.179
ISSN:1674-5515
年,卷(期):2024.39(5)
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