Effect of CYP2D6 gene polymorphism on serum concentration of aripiprazole and clinical efficacy in children with tic disorders
Objective To investigate the effect of CYP2D6 gene polymorphism on aripiprazole concentration and clinical efficacy in children with tic disorders treated with aripiprazole.Methods Children with tic disorders who were admitted to the Department of Child Health,Wuhan Children's Hospital,Tongji Medical College,from January 2021 to May 2022.Children were po administered with Aripiprazole Tablets in the morning,and the clinical efficacy and adverse reactions were observed and recorded before treatment and after 4 and 8 weeks of treatment.Blood samples were collected after reaching a stable state of treatment,and the serum concentrations of aripiprazole,dehydroariprazole,and CYP2D6 gene polymorphism were detected.Results There were statistically significant differences in the concentration/daily dosage per kilogram(C/D)value,YGTSS reduction rate,and effective rate of aripiprazole among ultra-rapid metabolizers groups,extensive metabolizers groups,and intermediated metabolizers groups(P<0.05),while there was no statistically significant difference in the incidence of adverse reactions among three groups.Conclusion CYP2D6 gene polymorphism could significantly affect the serum concentration and clinical efficacy of aripiprazole in treatment of children with tic disorders,which could provide reference for clinical individualized medicine.
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