Clinical study on Chuanzhi Tongluo Capsules combined with compound porcine cerebroside and ganglioside in treatment of acute cerebral infarction in recovery period
Objective To explore the therapeutic effect of Chuanzhi Tongluo Capsules combined with Compound Porcine Cerebroside and Ganglioside Injection in treatment of acute cerebral infarction in recovery period.Methods Patients(100 cases)with acute cerebral infarction in recovery period in the Fifth Affiliated Hospital of Zhengzhou University from January to December 2022 were divided into control and treatment groups according to the random number table method,and each group had 50 cases.Patients in the control group were iv administered with Compound Porcine Cerebroside and Ganglioside Injection,20 mL added into normal saline 300 mL,once daily.Patients in the treatment group were po administered with Chuanzhi Tongluo Capsules on the basis of the control group,0.5 g/time,three times daily.Patients in two groups were treated for 2 weeks.The clinical efficacies,scale scores,hemorheological indicators,nerve cytokines,and vascular endothelial function in two groups were compared.Results The total effective rate of treatment group(92.00%)was higher than 76.00%t of control group(P<0.05).After treatment,NIHSS scores in two groups was significantly decreased,and ADL scores in two groups was significantly increased(P<0.05).And NIHSS score and ADL score in the treatment group were significantly better than those in the control group(P<0.05).After treatment,the erythrocyte sedimentation rate,hematocrit,whole blood viscosity,and platelet adhesion rate of two groups were significantly decreased(P<0.05),and the erythrocyte sedimentation rate,hematocrit,whole blood viscosity,and platelet adhesion rate in the treatment group were lower than those in the control group(P<0.05).After treatment,the serum level of NSE in two groups was significantly decreased,but the serum levels of BDNF and NTF in two groups were significantly increased(P<0.05).And the serum neurocytokine level in the treatment group was better than that in the control group(P<0.05).After treatment,the serum levels of ET-1 and vWF in two groups were decreased,but the serum level of NO in two groups was increased(P<0.05),and the serum vascular endothelial function in the treatment group was better than that in the control group(P<0.05).Conclusion Chuanzhi Tongluo Capsules combined with Compound Porcine Cerebroside and Ganglioside Injection has clinical curative effect in treatment of acute cerebral infarction in recovery period,can enhance living ability,improve blood rheology,improve neurological function,and protect vascular endothelium.
Chuanzhi Tongluo CapsulesCompound Porcine Cerebroside and Ganglioside Injectionacute cerebral infarction in recovery periodNIHSS scoreADL scoreplatelet adhesion rateNSEBDNFNTFET-1vWFNO
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