Clinical study of Naoxueshuan Tablets combined with alteplase in treatment of acute cerebral infarction
Objective To explore the clinical efficacy of Naoxueshuan Tablets combined with ateplase in treatment of acute cerebral infarction.Methods 98 Patients with acute cerebral infarction admitted to Xi'an Gaoxin Hospital from March 2021 to June 2023 were divided into control group(49 cases)and treatment group(49 cases)by random number table method.Patients in the control group were given Alteplase for injection,the dosage was 0.9 mg/kg,with the maximum dosage not exceeding 90 mg,and 10%of the dosage was injected intravenously 1 min before the start of treatment,and the remaining dosage was injected continuously for 60 min,treated once,and basic treatment was continued after completion of thrombolysis.Patients in the treatment group were po administered with Naoxueshuan Tablets on the basis of the control group,6 tablets/time,three times daily.Both groups were treated continuously for 14 d.The clinical effects of the two groups were observed,and the Barthel scores,NIHSS scores,homocysteine(Hcy),interleukin-17(IL-17),C-reactive protein(CRP)and hemorheology were compared between two groups before and after treatment.Results After treatment,the total effective rate of treatment group was 95.92%,which was significantly higher than that of control group(81.63%,P<0.05).After treatment,the modified Barthel score in both groups was higher than before treatment,but the NIHSS score was lower than before treatment(P<0.05).After treatment,the modified Barthel score and NIHSS score were significantly improved in treatment group(P<0.05).After treatment,the levels of serum Hcy,IL-17,and CRP in 2 groups were lower than before treatment(P<0.05).After treatment,the levels of serum Hcy,IL-17,and CRP in treatment group were significantly improved(P<0.05).After treatment,the levels of whole blood viscosity,fibrinogen,and plasma viscosity under various shear rates were lower than before treatment(P<0.05).After treatment,the levels of whole blood viscosity,fibrinogen and plasma viscosity were significantly improved under various shear rates in treatment group(P<0.05).Conclusion Naoxueshuan Tablets combined with alteplase has good clinical efficacy in treatment of acute cerebral infarction,and can improve the neurological impairment and blood hypercoagulability of patients,and can improve the independent living ability of patients,which can effectively reduce the serum Hcy level and the inflammatory response with good safety.
Naoxueshuan TabletsAlteplase for injectionacute cerebral infarctionBarthel scoresNIHSS scoresHcyIL-17CRP
NETL
NSTL
万方数据
