Clinical study on Nuzhen Granules with zolpidem tartrate in treatment of Yin deficiency of liver and kidney
Objective To explore the clinical effect of Nuzhen Granules with zolpidem tartrate in treatment of Yin deficiency of liver and kidney.Methods Patients(100 cases)with Yin deficiency of liver and kidney in the First Affiliated Hospital of Henan University Chinese Medicine from January 2021 to March 2023 were randomly divided into control(50 cases)and treatment(50 cases)group.Patients in the control group were po administered with Zolpidem Tartrate Tablets,10 mg/time,once daily.Patients in the treatment group were po administered with Nuzhen Granules on the basis of the control group,6 g/time,three times daily.Patients in two groups were treated for 7 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,the scores of SPIEGEL and QOL,and the levels of GDNF,5-HT,COR and IL-1β in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 98.00%,which was significantly higher than that of the control group(84.00%,P<0.05).After treatment,the time of symptom relief in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the SPIEGEL score in two groups was significantly lower than that before treatment,while the QOL score was significantly increased(P<0.05),and the score of the treatment group was significantly better than that of the control group(P<0.05).After treatment,the serum levels of GDNF and 5-HT were significantly increased,while the levels of COR and IL-1β were significantly decreased in two groups(P<0.05),and the level of serum factors in the treatment group was significantly better than that in the control group(P<0.05).Conclusion Nuzhen Granules with zolpidem tartrate in treatment of Yin deficiency of liver and kidney can promote deep sleep,weaken inflammatory reaction and effectively improve the quality of life.
Nuzhen GranulesZolpidem Tartrate Tabletsperimenopausal periodinsomnia of liver and kidney yin deficiency typeSPIEGELQOLGDNFCOR
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