Clinical study on isosorbide mononitrate combined with sacubitril valsartan sodium in treatment of chronic heart failure
Objective To explore the clinical effect of Isosorbide Mononitrate Tablets combined with sacubitril valsartan sodium in treatment of chronic heart failure.Methods Patients(106 cases)with chronic heart failure in Beijing Luhe Hospital,Capital Medical University from July 2020 to November 2022 were divided into control and treatment group according to different treatment,and each group had 53 cases.Patients in the control group were po administered with Sacubitril Valsartan Sodium Tablets,100 mg/time,twice daily.Patients in the treatment group were po administered with Isosorbide Mononitrate Tablets on the basis of the control group,20 mg/time,twice daily.Patients in two groups were treated for 7 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,6MWT trials and ADL scores,and the levels of serum IL-1β,NT-proBNP,sST2 and SDC1 in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 94.33%,which was significantly higher than that of the control group(81.13%,P<0.05).After treatment,the improvement time of dyspnea,fatigue,fatigue and palpitation in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the scores of 6MWT test and ADL in two groups were significantly higher than those before treatment(P<0.05),and which in the treatment group were significantly higher than those in the control group(P<0.05).After treatment,the levels of serum IL-1β,NT-proBNP,sST2 and SDC1 in two groups were significantly lower than those before treatment(P<0.05),and which in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion The synergistic treatment of isosorbide mononitrate and sacubitril valsartan sodium can effectively improve the symptoms of heart failure,significantly improve the cardiac function and quality of daily life of patients,and weaken the inflammatory response,which is safe and effective,which is worth using for reference.
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