Objective To analyze the clinical efficacy of Wenxin Granules combined with clopidogrel in treatment of acute ST segment elevated myocardial infarction.Methods A total of 116 patients with acute ST-segment elevation myocardial infarction admitted to Beijing Friendship Hospital Affiliated to Capital Medical University from August 2021 to June 2023 were selected and divided into control group and treatment group according to random number table method,with 58 cases in each group.Patients in the control group were po administered with Clopidogrel Bisulfate Tablets,300 mg/time,once daily,after 7 d of continuous administration,75 mg/d,once daily.Patients in the treatment group were po administered with Wenxin granules on the basis of control group,1 bag/time,3 times daily.Both groups were treated continuously for 4 weeks.The clinical efficacy,markers of heart injury,echocardiogram and serum levels of amyloid A(SAA),interleukin-33(IL-33)and angiotensin 1-7[Ang(1-7)]were compared between two groups.Major adverse cardiac events(MACE)were measured in two groups.Results After treatment,the total effective rate of treatment group was 93.10%,which was significantly higher than 79.31%of control group(P<0.05).After treatment,the serum levels of B-type natriuretic peptide(BNP),creatine kinase isoenzyme(CK-MB),cardiac troponin I(cTnI),and soluble growth stimulation expression gene 2 protein(sST2)in 2 groups were significantly decreased(P<0.05).The decrease was more significant in treatment group(P<0.05).After treatment,left ventricular ejection fraction(LVEF)was significantly increased,but left atrial volume index(LAVI)and left atrial anterior and posterior diameter(LAD)were significantly decreased in both groups(P<0.05).The improvement was more significant in treatment group(P<0.05).After treatment,serum levels of SAA,IL-33,and Ang(1-7)in 2 groups were significantly decreased(P<0.05).The decrease was more significant in treatment group(P<0.05).After treatment,the incidence of MACE in treatment group was 5.17%,which was significantly lower than that in control group(17.24%,P<0.05).Conclusion Wenxin Granules combined with clopidogrel has high efficacy and safety in treatment of acute ST segment elevated myocardial infarction,and can effectively protects the cardiac function of patients,significantly reduces the degree of myocardial damage and body inflammation,and reduces cardiac adverse events,which is worthy of clinical promotion and application.
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