Objective To investigate the effect of Wenxin Granules combined with Verapamil Hydrochloride Injection in treatment of paroxysmal supraventricular tachycardia.Methods Patients(116 cases)with paroxysmal supraventricular tachycardia in Beijing Rehabilitation Hospital Affiliated to Capital Medical University from July 2021 to June 2023 were divided into control and treatment groups according to the random number table method,and each group had 58 cases.Patients in the control group were iv administered with Verapamil Hydrochloride Injection,5 mg drug added into normal saline 10 mL,iv within 3 min,observing for 20 min.If the condition did not improve,repeating the injection until recovery and stop.The daily dose did not exceed 50 mg.Patients in the treatment group were po administered with Wenxin Granules with boiling water on the basis of the control group,1 bag/time,three times daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical efficacies,attack and treatment status,ultrasound electrocardiogram examination,and cardiac function indicators in two groups were compared.Results The total effective rate of the treatment group was 93.10%,which was significantly higher than 79.31%of the control group,and the difference was statistically significant(P<0.05).After treatment,the attack frequency and average recovery time in the treatment group were lower than those before treatment,but the recovery rate within 30 min in the treatment group was higher than that before treatment(P<0.05).The frequency of attack and the mean recovery time of treatment group were lower than that of control group,but the recovery rate within 30 min of treatment group was higher than that of control group(P<0.05).After treatment,the number of short ventricular tachycles and the number of pre-ventricular contractions in the treatment group was smaller than those before treatment(P<0.05),and the number of short ventricular tachycles and the number of pre-ventricular contractions in the treatment group was smaller than those in the control group(P<0.05).After treatment,LVEF in two groups were significantly higher than those before treatment,but LVESV was significantly decreased(P<0.05).After treatment,LVEF in the treatment group were higher than those before treatment,but LVESV in the treatment group were lower than those in the control group(P<0.05).Conclusion Wenxin Granule combined with Verapamil Hydrochloride Injection can improve the therapeutic effect of paroxysmal supraventricular tachycardia,reduce the frequency of attacks,and improve cardiac function.
Wenxin GranulesVerapamil Hydrochloride Injectionparoxysmal supraventricular tachycardiaattack frequencyaverage recovery timerecovery rate within 30 minnumber of short ventricular tachyclenumber of pre-ventricular contractionLVEFLVESV
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