Objective To explore the clinical efficacy of Keluoxin Capsules combined with perindopril in treatment of early diabetes nephropathy.Methods A total of 168 patients with early diabetic nephropathy admitted to the Fifth Affiliated Hospital of Zhengzhou University from June 2021 to January 2023 were selected and divided into control group and treatment group according to random number table method,with 84 patients in each group.Patients in the control group were po administered with Perindopril tert-Butylamine Tablets in the morning,4 mg/d,once daily.Patients in the treatment group were po administered with Keluoxin Capsules on the basis of the control group,4 grains/time,three times daily.Both groups were treated for 12 weeks.The clinical efficacy of two groups was observed,and traditional Chinese medicine symptom scores,renal function indicators[24 hour urinary protein quantification(24-hour UP)],related scales[Kidney Disease Quality of Life Scale 1.3(KDQOL-SF 1.3),Simplified Depression Anxiety Stress Scale(DASS-21)]scores before and after treatment,as well as serum levels of angiogenic inhibitory protein-1(VASH-1),high mobility group protein B1(HMGB1),and CXC chemokine ligand 10(CXCL10)in two groups were compared.Results After treatment,the total effective rate of the treatment group was 94.05%,which was significantly higher than that of the control group(84.52%,P<0.05).After treatment,the scores of shortness of breath and fatigue,dry throat and thirst,limb numbness,limb numbness,waist and knee tenderness and cold limb fear were significantly decreased in both groups compared with before treatment(P<0.05).After treatment,the TCM symptom score of the treatment group was lower than that of the control group(P<0.05).After treatment,Scr,24 h UP and UAER in 2 groups were lower than before treatment(P<0.05).After treatment,the improvement of renal function index in treatment group was better than that in control group(P<0.05).After treatment,KDQOL-SF 1.3 score was significantly increased in both groups,while DASS-21 score was significantly decreased(P<0.05).After treatment,KDQOL-SF 1.3 and DASS-21 scores in the treatment group were better than those in the control group(P<0.05).After treatment,the serum levels of VASH-1,HMGB1 and CXCL10 in 2 groups were significantly decreased(P<0.05).After treatment,serum levels of VASH-1,HMGB1 and CXCL10 in the treatment group were lower than those in the control group(P<0.05).Conclusion Keluoxin Capsules combined with perindopril has good curative effect in treatment of early diabetes nephropathy,and can effectively relieve inflammation,control renal fibrosis,reduce symptoms and negative emotions,improve renal function and quality of life in patients,which is worthy of clinical application.
Keluoxin CapsulesPerindopril tert-Butylamine Tabletsdiabetes nephropathyTCM symptom score24 h UPkidney disease quality of life scale 1.3 scoreangiogenesis inhibitory protein 1high mobility group protein B1CXC chemokine ligand 10
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