Clinical study on Xihuang Pills combined with bevacizumab in treatment of advanced colorectal cancer
Objective To explore the therapeutic effect of Xihuang Pills combined with Bevacizumab Injection in treatment of advanced colorectal cancer.Methods Patients(86 cases)with advanced colorectal cancer in Baoding NO.1 Hospital from August 2021 to August 2023 were divided into control and treatment groups according to the random number table method,and each group had 43 cases.Patients in the control group were iv administered with Bevacizumab Injection,5 mg/(kg∙d),infusion duration of more than 90 min,once per two weeks.Patients in the treatment group were po administered with Xihuang Pills on the basis of the control group,3 g/time,twice daily.Patients in two groups were treated for 8 weeks.The clinical efficacies,QOL scores,KPS scores,and serum tumor marker levels in two groups were compared.Results Compared with the control group,ORR and CBR of the treatment group were higher(P<0.05).After treatment,KPS scores and QOL scores in two groups were significantly increased(P<0.05),and KPS scores and QOL scores in the treatment group were significantly higher than those in the control group(P<0.05).After treatment,the serum levels of CA19-9,CA125,CEA,and CA242 in two groups were significantly decreased(P<0.05),and the serum tumor marker levels in treatment group were significantly lower than those in control group(P<0.05).Conclusion Xihuang Pills combined with Bevacizumab Injection is effective in treatment of advanced colorectal cancer,can improve the quality of life of patients,reduce the level of tumor markers.
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