Clinical study of Jinshuibao Capsules combined with piperazine ferulate in treatment of chronic glomerulonephritis
Objective To explore the therapeutic effect of Jinshuibao Capsules combined with piperazine ferulate in treatment of chronic glomerulonephritis.Methods A total of 148 patients with chronic glomerulonephritis admitted to Meishan City People's Hospital from July 2021 to July 2023 were selected,and 148 patients with chronic glomerulonephritis were divided into control group(74 cases)and treatment group(74 cases)by random number table method.Patients in the control group were po administered with Piperazine Ferulate Tablets,100 mg/time,three times daily.Patients in the treatment group were po administered with Jinshuibao Capsules on the basis of the control group,6 grains/time,three times daily.Both groups were treated continuously for 3 months.The curative effect and the improvement time of TCM symptoms in two groups were observed,and the indexes of blood hypercoagulability and renal function before and after treatment were compared.Results After treatment,the total effective rate of the treatment group was 94.59%,which was significantly higher than that of the control group(83.78%,P<0.05).Compared with the control group,the improvement time of fatigue,facial edema and lumbar soreness in the treatment group was shorter(P<0.05).After 3 months of treatment,the levels of fibrinogen,D-dimer,and thromboxane B2(TXB2)in 2 groups were significantly decreased compared with before treatment(P<0.05).Compared with the control group,the levels of fibrinogen,D-dimer,and TXB2 in treatment group were lower after 3 months of treatment(P<0.05).After treatment,the levels of cystatin C(CysC),retinol-binding protein(RBP),urea nitrogen and creatinine were decreased in both groups,but the levels of glomerular filtration rate(eGFR)were increased(P<0.05).Compared with the control group,the levels of CysC,RBP,urea nitrogen,and creatinine in treatment group were lower after treatment,and the levels of eGFR were higher(P<0.05).Conclusion Jinshuibao Capsules combined with piperazine ferulate achieves ideal therapeutic effects in treatment of chronic glomerulonephritis,and has a significant improvement effect on blood hypercoagulability and renal function in patients,and there are no significant adverse reactions with high safety.
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