Clinical study on Shengji Yupi Ointment combined with Recombinant Bovine Basic Fibroblast Growth Factor Eye-Gel in treatment of chronic ulcer on body surface
Objective To explore the clinical effect of Shengji Yupi Ointment combined with Recombinant Bovine Basic Fibroblast Growth Factor Eye-Gel in treatment of chronic ulcer on body surface.Methods Patients(98 cases)with chronic ulcer on body surface in Tangshan Central Hospital from February 2021 to January 2023 were divided into control and treatment group based on different treatments,and each group had 49 cases.Patients in the control group were po administered with Recombinant Bovine Basic Fibroblast Growth Factor Eye-Gel,300 IU/cm2/time,once daily.Patients in the treatment group were administered with Shengji Yupi Ointment on the basis of the control group,once daily.Patients in two groups were treated for 14 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,the scores of VAS and QOL,and the levels of serum IL-1β,MMP-9,TNF-α and EGF in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 93.87%,which was significantly higher than that of the control group(81.63%,P<0.05).After treatment,the time of symptom improvement in the treatment group was significantly shorter than that in the control group(P<0.05).After treatment,the VAS score of the two groups was significantly decreased,while the QOL score was significantly increased(P<0.05),and the VAS and QOL scores of the treatment group were significantly better than those of the control group(P<0.05).After treatment,the serum levels of IL-1β,MMP-9 and TNF-α in two groups were significantly decreased,while the level of EGF was significantly increased(P<0.05),and the serological level in the treatment group was significantly better than that in the control group(P<0.05).Conclusion The combined treatment of Recombinant Bovine Basic Fibroblast Growth Factor Eye-Gel and Shengji Yupi Ointment can improve the symptoms of ulcer patients,reduce the degree of wound pain and improve the quality of life obviously.
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