Clinical study on Tripterygium Glycosides Tablets combined with Triamcinolone Acetonide Dental Paste in treatment of discoid lupus erythematosus
Objective To investigate the curative effect of Tripterygium Glycosides Tablets combined with Triamcinolone Acetonide Dental Paste in treatment of discoid lupus erythematosus.Methods Patients(94 cases)with discoid lupus erythematosus in Tangshan People's Hospital from January 2021 to May 2023 were divided into control and treatment groups according to the random number table method,and each group had 47 cases.Patients in the control group were treated with Triamcinolone Acetonide Dental Paste after breakfast and dinner,0.4 mg/time,twice daily,abstained from food and drink within 1 h after application.Patients in the treatment group were po administered with Tripterygium Glycosides Tablets on the basis of the control group,1—1.5 mg/time,three times daily.Patients in two groups were treated for 4 weeks.The clinical efficacies,the subjective pain degree,lesion area,and serum factor levels in two groups were compared.Results After treatment,the total effective rate of the control group was 78.72%,but the total effective rate of the treatment group was 93.62%,and the difference between the groups was significant(P<0.05).After treatment,VAS score of two groups was smaller than before treatment,and the lesion area of two groups was significantly reduced(P<0.05),and the VAS score of the treatment group was smaller than that of the control group,and the lesion area of the treatment group was smaller than that of the control group(P<0.05).After treatment,the levels of IL-2 in two groups were higher than before treatment,but the levels of OPN and IL-6 in two groups were lower than before treatment(P<0.05).After treatment,the levels of IL-2 in the treatment group were higher than those in the control group,but the levels of OPN and IL-6 in the treatment group were lower than those in the control group(P<0.05).Conclusion Tripterygium Glycosides Tablets combined with Triamcinolone Acetonide Dental Paste can improve the curative effect of discoid lupus erythematosus,help to reduce the degree of pain,lesion area,and inflammation.
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