Objective To analyze the clinical efficacy of Compound Gargle Solution Chlorhexidine Giuconaie combined with aciclovir in treatment of herpetic stomatitis in children.Methods A total of 112 children with herpetic stomatitis admitted to Shanghai Fourth People's Hospital Affiliated to Tongji University from January 2021 to July 2023 were selected and divided into control group and treatment group according to random number table method,with 56 cases in each group.Children in control group were iv administered with Aciclovir for injection,15 mg/kg was added into 5%glucose injection,diluted to 1 mg/mL,and then indribbled for more than 1 h,twice daily.Patients in treatment group were given Compound Gargle Solution Chlorhexidine Giuconaie on the basis of the control group,10 mL/time,spit out after 3 min,twice daily,and gargle after brushing in the morning and evening.The treatment course of both groups was 7 d.The clinical efficacy and disappearance time of clinical manifestations of two groups were observed,and the scores of Eating Behavior questionnaire(MBQ),Children's Sleeping Habits Questionnaire(CSHQ),whole blood lymphocyte count(LYmpU#)and serum prealbumin(PAB)were compared between two groups before and after treatment.Results After treatment,the total effective rate in the treatment group was 100.00%,which was significantly higher than 89.29%in control group(P<0.05).After treatment,the disappearance time of fever,irritability crying,food refusal,sore salivation,herpes and ulcer in the treatment group was significantly shorter than that in control group(P<0.05).After treatment,MBQ and CSHQ scores were significantly decreased in both groups(P<0.05).After treatment,MBQ and CSHQ scores in the treatment group were lower than those in the control group(P<0.05).After treatment,whole blood lympP#was significantly decreased,while serum PAB level was significantly increased in both groups(P<0.05).After treatment,the whole blood LYmpP#and serum PAB levels in treatment group were better than those in control group(P<0.05).Conclusion Compound Gargle Solution Chlorhexidine Giuconaie combined with aciclovir has good safety and efficacy in treatment of herpetic stomatitis in children,and can quickly alleviate the clinical manifestations of children,reduce the degree of viral infection,which can promote improvement in diet,sleep,and prognosis.
Compound Gargle Solution Chlorhexidine GiuconaieAciclovir for injectionherpetic stomatitis in childrenMBQ scoreCSHQ scoreLYMP#PAB
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