Mining adverse events and analysis of trilaciclib based on FAERS database
Objective To collect adverse drug event reports of trilaciclib based on FAERS database,explore new and serious adverse events,and provide reference for clinical safe drug use.Method Obtaining adverse event reports related to trilaciclib in FAERS from Q1 2004 to Q4 2023,and use a combination of ROR,PRR,BCPNN,and MGPS to mine and analyze adverse event reports.Results A total of 457 adverse drug event reports related to trilaciclib were obtained.Among trilaciclib reports of known gender,age,or region,the male to female ratio was similar,with the highest proportion of ADE reports occurring between the ages of 45 and 65.Adverse drug event report of trilaciclib involves 19 SOC,including systemic diseases and various reactions at the site of administration,various examinations,psychiatric disorders,etc.Positive signals mainly include use beyond the instructions and bone marrow suppression difficulty breathing,decreased physical condition,etc.Conclusion The adverse event signals of trilaciclib are effectively consistent with the instructions,and some new potential signals have been discovered,such as anxiety,mood depression,and nervousness,which are worthy of clinical attention.
trilaciclibadverse eventsFAERS databasedata mining and analysisbeyond the instructionsbone marrow suppression difficulty breathingdecreased physical condition
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