中药活性成分抑制哺乳动物雷帕霉素靶蛋白(mTOR)通路抗肿瘤作用的研究进展
Progress on anti-tumor effects of active ingredients in traditional Chinese medicine inhibiting mammalian target of rapamycin(mTOR)pathway
王渝 1张恒 2王华庆 2王辉2
作者信息
- 1. 天津中医药大学 研究生院,天津 301617;天津市人民医院 肿瘤诊治中心,天津 300121
- 2. 天津市人民医院 肿瘤诊治中心,天津 300121
- 折叠
摘要
哺乳动物雷帕霉素靶蛋白(mTOR)与癌症有密切关系,抑制mTOR通路可以发挥抗肿瘤作用.目前许多mTOR抑制剂被开发用于癌症的治疗.一些中药活性成分如蒽醌类、生物碱类、萜类、多糖类、黄酮类、多酚类成分可以通过抑制mTOR通路诱导肿瘤细胞凋亡、促进自噬、阻断细胞周期发挥抗肿瘤作用.总结了中药活性成分抑制 mTOR通路抗肿瘤作用的研究进展,明确其作用机制,为临床应用提供参考.
Abstract
Mammalian target of rapamycin(mTOR)is closely related to cancer,and inhibiting the mTOR pathway can exert anti-tumor effects.At present,many mTOR inhibitors are being developed for the treatment of cancer.Some active ingredients in traditional Chinese medicine,such as anthraquinone,alkaloids,terpenoids,polysaccharides,flavonoids,polyphenols,can exert anti-tumor effects by inhibiting the mTOR pathway through inducing tumor cell apoptosis,promoting autophagy,and blocking the cell cycle.This article summarizes the research progress on anti-tumor effects of active ingredients in traditional Chinese medicine through the mTOR pathway,clarifies their mechanisms of action,and provides reference for clinical applications.
关键词
蒽醌/生物碱/萜类/多糖/黄酮/多酚/哺乳动物雷帕霉素靶蛋白信号通路/抗肿瘤作用Key words
anthraquinone/alkaloid/terpenoid/polysaccharide/flavonoid/polyphenol/mTOR signaling pathway/anti-tumor effect引用本文复制引用
基金项目
国家自然科学基金面上项目(81972847)
天津市自然科学基金多元投入基金(21JCYBJC01830)
天津市医学重点学科(专科)建设项目(TJYXZDXK-053B)
天津市人民医院院级项目(2022ZLXK01)
天津市人民医院院级项目(2022ZLXK07)
出版年
2024
NETL
NSTL
万方数据