Research progress on genetic factors of high on-treatment platelet reactivity and its drug treatment strategies
Antiplatelet drugs are currently commonly used in the treatment of ischemic heart disease,mainly including clopidogrel and aspirin.However,they are easy to develop clopidogrel resistance and aspirin resistance,both of which belong to high on-treatment platelet reactivity after anticoagulation therapy.The influence of genetic factors on high on-treatment platelet reactivity is crucial.At present,personalized antiplatelet therapy is the main treatment strategy for high on-treatment platelet reactivity,and commonly used drugs include ticagrelor,αIIbβ3 antagonists,and traditional Chinese medicine.This article summarizes the research progress on genetic factors and treatment strategies of high on-treatment platelet reactivity,to provide clinical reference for the treatment of high on-treatment platelet reactivity.
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