Research progress of tanshinone ⅡA in prevention and treatment of osteoarthritis
Osteoarthritis is a disabling disease characterized by dedifferentiation of chondrocytes,cartilage degeneration,and cartilage defects.At present,there is a lack of effective drugs,and clinical treatment mainly focuses on alleviating symptoms.Tanshinone ⅡA is a lipophilic component from Salviae Miltiorrhizae Radix et Rhizoma,which has multiple pharmacological effects.Tanshinone ⅡA can reduce inflammation and protect cartilage tissue to prevent and treat osteoarthritis.This article summarizes the research progress of tanshinone ⅡA in prevention and treatment of osteoarthritis,summarizes its mechanism,and provides reference for the clinical treatment of osteoarthritis with tanshinone ⅡA.
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