Box-Behnken响应面法优化荆芥穗挥发油β-环糊精包合物的高速剪切包合工艺

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中文摘要：目的优化荆芥穗挥发油β-环糊精包合物的高速剪切包合工艺。方法在单因素考察的基础上，以包合物收率、胡薄荷酮包合率的综合评分为评价指标，以β-环糊精与挥发油倍量比、剪切转速和剪切包合时间为考察因素，采用Box-Behnken响应面法进行包合工艺优化，通过Design-Expert 13 软件分析各因素的交互作用优选最佳工艺条件。结果采用高速剪切法制备荆芥穗挥发油β-环糊精包合物的最佳工艺参数为β-环糊精与挥发油倍量比为 8∶1，β-环糊精与纯化水倍量比 1∶8，剪切包合时间 40 min，剪切转速为 7 700 r/min。结论优化后的工艺包合率和收率较高，工艺合理可行，对后续产品的研究和生产具有一定指导作用。

外文标题：Optimization of high-speed shear inclusion process on Schizonepetae Spica volatile oil-β-cyclodextrin inclusion complex by Box-Behnken response surface method

外文摘要：Objective To optimize the high-speed shear inclusion process on Schizonepetae Spica volatile oil-β-cyclodextrin inclusion complex.Methods On the basis of single factor test,the inclusion process was optimized by Box-Behnken response surface method with the comprehensive score of inclusion complex yield and pulegone inclusion rate as the evaluation index,and mass ratio of β-cyclodextrin to volatile oil,shear speed,and shear time as the investigation factors.The optimum process conditions were selected by analyzing the interaction of various factors by Design-Expert 13 software.Results The optimum process parameters of preparing Schizonepetae Spica volatile oil-β-cyclodextrin inclusion complex by high-speed shearing method were as following:the ratio of β-cyclodextrin to volatile oil was 8∶1,the mass ratio of β-cyclodextrin to purified water was 1∶8,the shearing inclusion time was 40 min,and the shearing speed was 7 700 r/min.Conclusion The optimized process has high inclusion rate and inclusion yield,and the process is reasonable and feasible,which has a certain guiding role for the research and production of subsequent products.

外文关键词：

Schizonepetae Spica volatile oil-β-cyclodextrin inclusion complexhigh speed shearinclusion processyieldinclusion rateBox-Behnken response surface method

作者：

郝晓卓、姜国志、李军山

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作者单位：

神威药业集团有限公司,河北石家庄 051430

云南省配方颗粒重点实验室,云南楚雄 675000

云南神威施普瑞药业有限公司,云南楚雄 675000

关键词：

荆芥穗挥发油β-环糊精包合物高速剪切包合工艺收率包合率 Box-Behnken响应面法

基金：

云南省科技重大专项云南省科技人才与平台计划石家庄市产业技术研究院建设任务项目

项目编号：

202102AA310027202105AG070014228790779A

出版年：

2024

DOI：

10.7501/j.issn.1674-5515.2024.06.011

现代药物与临床

天津药物研究院,中国药学会

现代药物与临床

CSTPCD

影响因子：1.179

ISSN：1674-5515

年,卷(期)：2024.39(6)