Box-Behnken响应面法优化荆芥穗挥发油β-环糊精包合物的高速剪切包合工艺
Optimization of high-speed shear inclusion process on Schizonepetae Spica volatile oil-β-cyclodextrin inclusion complex by Box-Behnken response surface method
郝晓卓 1姜国志 1李军山2
作者信息
- 1. 神威药业集团有限公司,河北 石家庄 051430
- 2. 神威药业集团有限公司,河北 石家庄 051430;云南省配方颗粒重点实验室,云南 楚雄 675000;云南神威施普瑞药业有限公司,云南 楚雄 675000
- 折叠
摘要
目的 优化荆芥穗挥发油β-环糊精包合物的高速剪切包合工艺.方法 在单因素考察的基础上,以包合物收率、胡薄荷酮包合率的综合评分为评价指标,以β-环糊精与挥发油倍量比、剪切转速和剪切包合时间为考察因素,采用Box-Behnken响应面法进行包合工艺优化,通过Design-Expert 13 软件分析各因素的交互作用优选最佳工艺条件.结果 采用高速剪切法制备荆芥穗挥发油β-环糊精包合物的最佳工艺参数为β-环糊精与挥发油倍量比为 8∶1,β-环糊精与纯化水倍量比 1∶8,剪切包合时间 40 min,剪切转速为 7 700 r/min.结论 优化后的工艺包合率和收率较高,工艺合理可行,对后续产品的研究和生产具有一定指导作用.
Abstract
Objective To optimize the high-speed shear inclusion process on Schizonepetae Spica volatile oil-β-cyclodextrin inclusion complex.Methods On the basis of single factor test,the inclusion process was optimized by Box-Behnken response surface method with the comprehensive score of inclusion complex yield and pulegone inclusion rate as the evaluation index,and mass ratio of β-cyclodextrin to volatile oil,shear speed,and shear time as the investigation factors.The optimum process conditions were selected by analyzing the interaction of various factors by Design-Expert 13 software.Results The optimum process parameters of preparing Schizonepetae Spica volatile oil-β-cyclodextrin inclusion complex by high-speed shearing method were as following:the ratio of β-cyclodextrin to volatile oil was 8∶1,the mass ratio of β-cyclodextrin to purified water was 1∶8,the shearing inclusion time was 40 min,and the shearing speed was 7 700 r/min.Conclusion The optimized process has high inclusion rate and inclusion yield,and the process is reasonable and feasible,which has a certain guiding role for the research and production of subsequent products.
关键词
荆芥穗挥发油β-环糊精包合物/高速剪切/包合工艺/收率/包合率/Box-Behnken响应面法Key words
Schizonepetae Spica volatile oil-β-cyclodextrin inclusion complex/high speed shear/inclusion process/yield/inclusion rate/Box-Behnken response surface method引用本文复制引用
基金项目
云南省科技重大专项(202102AA310027)
云南省科技人才与平台计划(202105AG070014)
石家庄市产业技术研究院建设任务项目(228790779A)
出版年
2024
NETL
NSTL
万方数据