Objective To explore the therapeutic effect of Xingxiong Sodium Chloride Injection combined with agatroban in treatment of acute cerebral infarction.Methods Patients(108 cases)with acute cerebral infarction in Xianyang Hospital of Yan'an University from June 2022 to July 2023 were divided into control(54 cases)and treatment(54 cases)group according to the random number table method.Patients in the control group were iv administered with Argatroban Injection,the dose was 2.5 mg/h in the first 2 d,and then the dose was 10 mg/time,intravenous drip was completed in about 3 h,twice daily,and the dose was used continuously for 5 d.Patients in the treatment group were iv administered with Xingxiong Sodium Chloride Injection on the basis of the control group,100 mL/time,once daily.Patients in two groups were treated for 7 d.After treatment,the clinical evaluations were evaluated,the levels of sVCAM-1,IL-1β,D-dimer and fibrinogen,NIHSS sores and 90 day prognosis in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 94.44%,which was significantly higher than that of the control group(81.48%,P<0.05).After treatment,the levels of sVCAM-1,IL-1β,D-dimer,fibrinogen,and NIHSS scores in two groups were significantly decreased(P<0.05),and which in the treatment group were significantly lower than those in the control group(P<0.05).The rate of good prognosis at 90 days in the treatment group was 88.89%,while that in the control group was 74.07%,there was significant difference between two groups(P<0.05).Conclusion Agatroban combined with Xingxiong Sodium Chloride Injection is effective and safe in the treatment of acute cerebral infarction,which can improve inflammatory reaction,blood hypercoagulable state and neurological function in vivo.
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