Clinical study of pentoxifylline combined with ozagrel sodium in treatment of acute cerebral infarction
Objective To analyze the clinical efficacy of Ozagrel Sodium for injection combined with pentoxifylline in treatment of acute cerebral infarction.Methods A total of 112 patients with acute cerebral infarction admitted to Beijing Fengtai Hospital of Integrated Chinese and Western Medicine from March 2015 to October 2020 were selected and divided into control group and treatment group according to random number table method,with 56 cases in each group.Patients in the control group were iv administered with Ozagrel Sodium for injection,80 mg/time,dissolved in 500 mL normal saline,twice daily.Patients in the treatment group were iv administered with Pentoxifylline for injection on the basis of the control group,0.2 g/time,dissolved in 250 mL normal saline,once daily,the patient was supine during the infusion,and the infusion was completed within 2 to 3 h.The treatment course of both groups was 14 d.The clinical efficacy of the two groups was observed.After treatment,NIHSS score,FMA score,SS-QOL score,PCT,PAgT,FIB,NLR,and PLR in two groups before and after treatment were compared.Results After treatment,the total effective rate of the treatment group was 94.64%,which was significantly higher than that of the control group(82.14%,P<0.05).After 3,7 and 14 days of treatment,NIHSS scores in 2 groups were significantly lower than before treatment(P<0.05).After treatment,the NIHSS score in the treatment group was significantly lower than that in the control group(P<0.05).After treatment,FMA and SS-QOL scores in both groups were significantly increased compared with those before treatment(P<0.05).After treatment,FMA and SS-QOL scores in the treatment group were higher than those in the control group(P<0.05).After treatment,PCT,PAgT,FIB,NLR,and PLR in two groups were significantly decreased(P<0.05).After treatment,coagulation and inflammation related indexes in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Ozagrel Sodium for injection combined with pentoxifylline has a definite effect in treatment of acute cerebral infarction,and can effectively promote the recovery of nerve function and motor function of patients,improve coagulation dysfunction and inflammation damage of the body,and improve the survival state of patients on the basis of better safety.
Pentoxifylline for injectionOzagrel Sodium for injectionacute cerebral infarctionNIHSS scoreFMA scoreSS-QOL scorePCTPagTFIBNLR
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